Ah, got it. It's Ween: The Prophecy.

I played the demo when I was only a wee Bairn Blubba. Been meaning to try the full game for a while now.

Yes Baron its Ween , you should certainly try the full version , highly recommended! plz continue

I'm 100% sure that I played this game; I remember some live-action scenes.
I also remember a screen with fire or lava at the end of the game. By that point,  I just wanted to finish the game, so I either used hints or watched it on YouTube.
Does it have a remake?

The last level has fire or lava I think and I had to use a walkthrough too, to input a code to open something (not with numbers, but slider stones). To this day I never understood how you could figure out the code on your one. Its the only puzzle in the game I didn't understand

Anyway Baron your turn

I humbly submit the greatest screenshot ever posted in the Adventure Game Scene Game game.

Hahaha,what is this lmao. I don't know Inca 2 ?

Nope! Although those guys might be able to start a band called Inca 3.

Some adventure game Crusaders might Arkue that this game belongs in a museum, but its Destiny is probably to be Doomed to be forgotten entirely except for these posts and the website I cribbed the screenshots from. 

Ok It's definitely an Indiana Jones game... ;-)

Some adventure game Crusaders might Arkue that this game belongs in a museum, but its Destiny is probably to be Doomed to be forgotten entirely except for these posts and the website I cribbed the screenshots from. 

Crusaders - indy 3
Ark - indy 1
Destiny - indy 5
Doom - indy 2

Sooo... <something> Skull <something>?
it's definitely not 3 Skulls of the Toltecs

Joe has seen clear through my clue and is on the right track.

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Joe basically solved the puzzle, he just haven't connected all the dots.

The game must be The Crystal Skull: A Mythic Aztec Adventure.